This study evaluated the available TBBPA biomonitoring and toxicology data to develop a TBBPA biomonitoring equivalent (BE) and to assess safety margins relative to potential exposure.
This study showed that human exposure to TBBPA is low; TBBPA blood concentrations are below concentrations of concern when comparing measured values to calculated BEs for cancer or other health related endpoints; and there are large safety margins for potential exposures to TBBPA.1 Source: Hays, Sean M., and Christopher R. Kirman. “Biomonitoring Equivalents (BEs) for tetrabromobisphenol A.” Regulatory Toxicology and Pharmacology 102 (2019): 108-114.
Key Takeaways:
- Comparing the derived biomonitoring equivalent to the available biomonitoring studies suggests a margin of safety (MOS) > 40, which suggests that human health risk from consumer or environmental exposures would be low.
- Comparing the biomonitoring data to the potential adverse health endpoints suggests a large margins of exposure (MOE) in excess of 2000, which suggests that human health risk from consumer or environmental exposures would be low.
