This study developed a no-significant-risk-level for TBBPA. The results of this review also noted that the weight of evidence from animal studies indicates that TBBPA has low toxicity. The review also suggested that high doses over long exposure durations would be needed to induce uterine tumor formation.1Source: Pecquet, Alison M., et al. “Derivation of a no‐significant‐risk‐level for tetrabromobisphenol A based on a threshold non‐mutagenic cancer mode of action.” Journal of Applied Toxicology 38.6 (2018): 862-878.
Key Takeaways:
- The weight of evidence from animal studies indicates that TBBPA has low toxicity and suggests that high doses over long exposure durations are needed to induce uterine tumor formation.
- The scientists determined that the available science supports the use of a non-linear threshold model rather than the linear extrapolation approach generally used by California’s OEHHA to calculate No Significant Risk Level (NSRL) values. Using this available data, a safe exposure threshold was derived for TBBPA.
